{"id":82,"date":"2020-06-10T02:14:52","date_gmt":"2020-06-10T02:14:52","guid":{"rendered":"http:\/\/sird.nagahama-i-bio.ac.jp\/blog\/?page_id=82"},"modified":"2020-06-16T00:23:55","modified_gmt":"2020-06-16T00:23:55","slug":"designing-drugs","status":"publish","type":"page","link":"https:\/\/sird.nagahama-i-bio.ac.jp\/blog\/?page_id=82","title":{"rendered":"Designing Drugs"},"content":{"rendered":"\n

\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u3067\u533b\u85ac\u54c1\u3092\u30c7\u30b6\u30a4\u30f3\u3059\u308b<\/strong><\/p>\n\n\n\n

\u533b\u85ac\u54c1(\u30c9\u30e9\u30c3\u30b0)\u306f\u53e4\u4ee3\u304b\u3089\u4eba\u985e\u306b\u3068\u3063\u3066\u69d8\u3005\u306a\u75be\u60a3\u3068\u6226\u3046\u305f\u3081\u306b\u4e0d\u53ef\u6b20\u306e\u6b66\u5668\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u30c9\u30e9\u30c3\u30b0\u3092\u8ad6\u7406\u7684\b\u306b\u63a2\u7d22\u30fb\u30c7\u30b6\u30a4\u30f3\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u3063\u305f\u306e\u306f\u3054\u304f\u6700\u8fd1\u306e\u3053\u3068\u3067\u3059\u3002\u3053\u3053\u3067\u3082\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u907a\u4f1d\u5b50\u306e\u60c5\u5831\u3092\u89e3\u6790\u3059\u308b\u624b\u6bb5\u304c\u5fc5\u9808\u306e\u65b9\u6cd5\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30c7\u30fc\u30bf\u30b5\u30a4\u30a8\u30f3\u30b9\u30fb\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u306e\u65b9\u6cd5\u8ad6\u3084\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u3067\u3001\u533b\u85ac\u54c1\u306e\u958b\u767a\u3092\u57fa\u790e\u304b\u3089\u652f\u63f4\u3059\u308b\u305f\u3081\u306e\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059(\u5275\u85ac\u7b49\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u4e8b\u696d BINDS<\/a>)\u3002\"\"<\/p>\n\n\n\n

\u751f\u85ac(\u30ca\u30c1\u30e5\u30e9\u30eb\u30c9\u30e9\u30c3\u30b0)\u306e\u5fdc\u7528<\/strong>
\u53e4\u6765\u304b\u3089\u7d4c\u9a13\u7684\u306b\u533b\u85ac\u54c1\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u3066\u304d\u305f\u751f\u85ac\u306e\u4e2d\u306b\u306f\u5b9f\u969b\u306b\u52b9\u679c\u3092\u3082\u3064\u3082\u306e\u304c\u3042\u308a\u3001\u3044\u304f\u3064\u304b\u306f\u8fd1\u4ee3\u7684\u306a\u533b\u85ac\u54c1\u3068\u3057\u3066\u5fdc\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u3053\u3067\u3053\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u751f\u85ac\u306b\u3082\u3068\u3065\u3044\u305f\u30c9\u30e9\u30c3\u30b0\u30c7\u30b6\u30a4\u30f3\u306b\u7740\u76ee\u3057\u3001\u5948\u826f\u5148\u7aef\u5927\u5b66\u9662\u5927\u5b66\u3068\u306e\u5171\u540c\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002
\u6700\u8fd1\u306e\u6210\u679c\u3068\u3057\u3066\u3001\u751f\u85ac\u30a6\u30b3\u30f3\u306e\u6709\u52b9\u6210\u5206\u3067\u3042\u308b\u30af\u30eb\u30af\u30df\u30f3\u3084\u305d\u306e\u8a98\u5c0e\u4f53(\u985e\u4f3c\u69cb\u9020\u3092\u3082\u3064\u5206\u5b50)\u306e\b\u5206\u5b50\u69cb\u9020\u3068\u6297\u304c\u3093\u6d3b\u6027\u306e\u76f8\u95a2\u3092\u3001\u30c9\u30c3\u30ad\u30f3\u30b0\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3084PCA(\u4e3b\u6210\u5206)\u5206\u6790\u3067\u89e3\u6790\u3057\u305f\u7d50\u679c\u3092\u5831\u544a\u3057\u307e\u3057\u305f(Sci Rep 2019<\/a>, Molecules 2019<\/a>)\u3002\"\"<\/p>\n\n\n\n

\u75be\u60a3\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u69cb\u9020\u306e\u7814\u7a76<\/strong>
\u72c2\u725b\u75c5\u30fb\u30af\u30ed\u30a4\u30c4\u30d5\u30a7\u30eb\u30c8-\u30e4\u30b3\u30d6\u75c5(CJD)\u306f\u795e\u7d4c\u7d30\u80de\u306e\u7d30\u80de\u6b7b\u304b\u3089\u8a8d\u77e5\u6a5f\u80fd\u30fb\u904b\u52d5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u7d4c\u3066\u6b7b\u306b\u81f3\u308b\u91cd\u7be4\u306a\u75be\u60a3\u3067\u3001\u307e\u3060\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u304c\u767a\u898b\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u306e\u75be\u60a3\u306f\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u306e\u75c5\u539f\u4f53\u3067\u306f\u306a\u304f\u3001\u30d7\u30ea\u30aa\u30f3(PrPc)\u3068\u3044\u3046\u30d2\u30c8\u306e\u4f53\u5185\u306b\u666e\u901a\u306b\u5b58\u5728\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u304c\u5909\u5316(PrPSc)\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u8d77\u3053\u308b\u300c\u30d5\u30a9\u30fc\u30eb\u30c9\u75c5\u300d\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u75be\u60a3\u539f\u56e0\u3068\u3055\u308c\u308bPrPSc\u306e\u7acb\u4f53\u69cb\u9020\u306f\u307e\u3060\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u3053\u306e\u7814\u7a76\u5ba4\u3067\u306f\u6771\u5317\u5927\u5b66\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u3001PrP\u306e\u7db2\u7f85\u7684\u5909\u7570\u5b9f\u9a13\u306e\u7d50\u679c\u3092\u3001\u8a08\u7b97\u6a5f\u3067\u3067\u30e2\u30c7\u30ea\u30f3\u30b0\u3057\u305f\u3044\u304f\u3064\u304b\u306ePrPSc\u69cb\u9020\u4e0a\u3067\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3067\u3001\u65b0\u898f\u306ePrPSc\u30e2\u30c7\u30eb(BH4)\u3092\u63d0\u5531\u3057\u307e\u3057\u305f(Structure 2014<\/a>)\u3002\"\"<\/p>\n\n\n\n

2020\u5e74\u306b\u5927\u304d\u306a\u793e\u4f1a\u554f\u984c\u3068\u306a\u3063\u305f\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u75c7(COVID-19)\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306b\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9(SARS-CoV-2)\u306e\u30bf\u30f3\u30d1\u30af\u8cea\b\u69cb\u9020\u3068\u3001\u65e2\u77e5\u306e\u30c9\u30e9\u30c3\u30b0\u306e\u8907\u5408\u4f53\u69cb\u9020\u306e\u8a08\u7b97\u6a5f\u30e2\u30c7\u30ea\u30f3\u30b0\u3092\u884c\u3044\u7d50\u679c\u3092\u5831\u544a\u3057\u307e\u3057\u305f(FEBS Lett 2020<\/a>, BSM-Arc<\/a>, BINDS-HP<\/a>)\u3002
\u3055\u3089\u306b\u3001\u3053\u306e\u7814\u7a76\u5ba4\u3067\u958b\u767a\u3057\u305f\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u7528\u3044\u3066\u30c9\u30e9\u30c3\u30b0\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u652f\u63f4\u3059\u308b\u3053\u3068\u3067\u3001COVID-19\u306b\u6709\u52b9\u306a2\u3064\u306e\u65e2\u5b58\u85ac\u306e\u767a\u898b\u306b\u5bc4\u4e0e\u3057\u307e\u3057\u305f\uff08\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b92020<\/a>\uff09\u3002 \"\"<\/p>\n\n\n\n

\u75be\u60a3-\u30c9\u30e9\u30c3\u30b0\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u89e3\u6790<\/strong>
\u30d2\u30c8\u306e\u69d8\u3005\u306a\u75be\u60a3\u30fb\u305d\u306e\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u30fb\u65e2\u5b58\u306e\u30c9\u30e9\u30c3\u30b0\u30fb\u305d\u306e\u30c9\u30e9\u30c3\u30b0\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u60c5\u5831\u84c4\u7a4d\u306f\u6025\u901f\u306b\u9032\u3093\u3067\u3044\u307e\u3059\u304c\u3001\u305d\u308c\u3089\u306f\u3068\u3066\u3082\u8907\u96d1\u306a\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u5f62\u6210\u3057\u3066\u3044\u3066\u3001\u4e00\u76ee\u3067\u30c9\u30e9\u30c3\u30b0\u3068\u75be\u60a3\u306e\u95a2\u4fc2\u6027\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u306f\u4e0d\u53ef\u80fd\u3067\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u5834\u5408\u3001\u30c7\u30fc\u30bf\u30b5\u30a4\u30a8\u30f3\u30b9\u30fb\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u306b\u3088\u308b\u89e3\u6790\u304c\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u5ba4\u3067\u306fDTX(Drug Target Excavator)<\/a>\u3068\u3044\u3046\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u30b7\u30b9\u30c6\u30e0\u3092\u69cb\u7bc9\u3059\u308b\u3059\u308b\u3053\u3068\u3067\u3001\u65b0\u305f\u306a\u30c9\u30e9\u30c3\u30b0\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u8ad6\u7406\u7684\u306b\u767a\u898b\u3059\u308b\u65b9\u6cd5\u306e\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u3067\u533b\u85ac\u54c1\u3092\u30c7\u30b6\u30a4\u30f3\u3059\u308b \u533b\u85ac\u54c1(\u30c9\u30e9\u30c3\u30b0)\u306f\u53e4\u4ee3\u304b\u3089\u4eba\u985e\u306b\u3068\u3063\u3066\u69d8\u3005\u306a\u75be\u60a3\u3068\u6226\u3046\u305f\u3081\u306b\u4e0d\u53ef\u6b20\u306e\u6b66\u5668\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u30c9\u30e9\u30c3\u30b0\u3092\u8ad6\u7406\u7684\b\u306b\u63a2\u7d22\u30fb\u30c7\u30b6\u30a4\u30f3\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u3063\u305f\u306e\u306f\u3054\u304f\u6700\u8fd1\u306e\u3053\u3068\u3067\u3059\u3002\u3053\u3053\u3067\u3082\u30bf\u30f3 … <\/p>\n

“Designing Drugs” \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-82","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/sird.nagahama-i-bio.ac.jp\/blog\/index.php?rest_route=\/wp\/v2\/pages\/82","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sird.nagahama-i-bio.ac.jp\/blog\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sird.nagahama-i-bio.ac.jp\/blog\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sird.nagahama-i-bio.ac.jp\/blog\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sird.nagahama-i-bio.ac.jp\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=82"}],"version-history":[{"count":10,"href":"https:\/\/sird.nagahama-i-bio.ac.jp\/blog\/index.php?rest_route=\/wp\/v2\/pages\/82\/revisions"}],"predecessor-version":[{"id":259,"href":"https:\/\/sird.nagahama-i-bio.ac.jp\/blog\/index.php?rest_route=\/wp\/v2\/pages\/82\/revisions\/259"}],"up":[{"embeddable":true,"href":"https:\/\/sird.nagahama-i-bio.ac.jp\/blog\/index.php?rest_route=\/wp\/v2\/pages\/2"}],"wp:attachment":[{"href":"https:\/\/sird.nagahama-i-bio.ac.jp\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=82"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}